Dr Fredrik Svensson

Postdoctoral research fellow working in the Bender group.

Publications

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity

D Steadman, BN Atkinson, Y Zhao, NJ Willis, S Frew, A Monaghan, C Patel, E Armstrong, K Costelloe, L Magno, M Bictash, EY Jones, PV Fish, F Svensson

Journal of medicinal chemistry

(2021)

562

(doi: 10.1021/acs.jmedchem.1c01735)

Synergy conformal prediction applied to large-scale bioactivity datasets and in federated learning.

U Norinder, O Spjuth, F Svensson

Journal of cheminformatics

(2021)

(doi: 10.1186/s13321-021-00555-7)

Structural Insights into Notum Covalent Inhibition

Y Zhao, F Svensson, D Steadman, S Frew, A Monaghan, M Bictash, T Moreira, R Chalk, W Lu, PV Fish, EY Jones

Journal of Medicinal Chemistry

(2021)

11354

(doi: 10.1021/acs.jmedchem.1c00701)

Deep Learning-Based Conformal Prediction of Toxicity

J Zhang, U Norinder, F Svensson

Journal of Chemical Information and Modeling

(2021)

2648

(doi: 10.1021/acs.jcim.1c00208)

Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.

ED Bayle, F Svensson, BN Atkinson, D Steadman, NJ Willis, HL Woodward, P Whiting, J-P Vincent, PV Fish

Journal of medicinal chemistry

(2021)

4289

(doi: 10.1021/acs.jmedchem.0c01974)

Assessing the Calibration in Toxicological in Vitro Models with Conformal Prediction

A Morger, F Svensson, SA McShane, N Gauraha, U Norinder, O Spjuth, A Volkamer

(2021)

(doi: 10.21203/rs.3.rs-220364/v1)

Systematic Analysis of Protein Targets Associated with Adverse Events of Drugs from Clinical Trials and Postmarketing Reports.

IA Smit, AM Afzal, CHG Allen, F Svensson, T Hanser, A Bender

Chemical research in toxicology

(2020)

365

(doi: 10.1021/acs.chemrestox.0c00294)

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.

W Mahy, NJ Willis, Y Zhao, HL Woodward, F Svensson, J Sipthorp, L Vecchia, RR Ruza, J Hillier, S Kjær, S Frew, A Monaghan, M Bictash, PC Salinas, P Whiting, J-P Vincent, EY Jones, PV Fish

J Med Chem

(2020)

12942

(doi: 10.1021/acs.jmedchem.0c01391)

Changing the HTS Paradigm: AI-Driven Iterative Screening for Hit Finding.

GHS Dreiman, M Bictash, PV Fish, L Griffin, F Svensson

SLAS Discovery

(2020)

257

(doi: 10.1177/2472555220949495)

Screening of a Custom-Designed Acid Fragment Library Identifies 1‑Phenylpyrroles and 1‑Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity

W Mahy, M Patel, D Steadman, HL Woodward, BN Atkinson, F Svensson, NJ Willis, A Flint, D Papatheodorou, Y Zhao, L Vecchia, RR Ruza, J Hillier, S Frew, A Monaghan, A Costa, M Bictash, MW Walter, EY Jones, PV Fish

J Med Chem

(2020)

9464

(doi: 10.1021/acs.jmedchem.0c00660)

Dr Fredrik Svensson

Publications

About the Department

Departmental Services

Bender Group

Study at Cambridge

About the University

Research at Cambridge