Dr Fredrik Svensson | Data-Driven Drug Discovery and Molecular Informatics

Postdoctoral research fellow working in the Bender group.

Publications

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.

W Mahy, M Patel, D Steadman, HL Woodward, BN Atkinson, F Svensson, NJ Willis, A Flint, D Papatheodorou, Y Zhao, L Vecchia, RR Ruza, J Hillier, S Frew, A Monaghan, A Costa, M Bictash, MW Walter, EY Jones, PV Fish

Journal of medicinal chemistry

(2020)

63

9464

(doi: 10.1021/acs.jmedchem.0c00660)

Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports

I Smit, A Afzal, C Allen, F Svensson, T Hanser, A Bender

(2020)

2020.06.12.135939

(doi: 10.1101/2020.06.12.135939)

Using Predicted Bioactivity Profiles to Improve Predictive Modeling

U Norinder, O Spjuth, F Svensson

Journal of chemical information and modeling

(2020)

60

2830

(doi: 10.1021/acs.jcim.0c00250)

Computational Chemistry on a Budget: Supporting Drug Discovery with Limited Resources

H Willems, S De Cesco, F Svensson

Journal of Medicinal Chemistry

(2020)

63

10158

(doi: 10.1021/acs.jmedchem.9b02126)

LightGBM: An Effective and Scalable Algorithm for Prediction of Chemical Toxicity−Application to the Tox21 and Mutagenicity Data Sets

J Zhang, D Mucs, U Norinder, F Svensson

Journal of chemical information and modeling

(2019)

59

4150

(doi: 10.1021/acs.jcim.9b00633)

Understanding Conditional Associations between ToxCast in Vitro Readouts and the Hepatotoxicity of Compounds Using Rule-Based Methods

SY Mahmoud, F Svensson, A Zoufir, D Módos, AM Afzal, A Bender

Chem Res Toxicol

(2019)

33

137

(doi: 10.1021/acs.chemrestox.8b00382)

Multitask Modeling with Confidence Using Matrix Factorization and Conformal Prediction

U Norinder, F Svensson

Journal of chemical information and modeling

(2019)

59

1598

(doi: 10.1021/acs.jcim.9b00027)

Maximizing gain in high-throughput screening using conformal prediction

F Svensson, AM Avid, U Norinder, A Bender

Journal of Cheminformatics

(2018)

10

7

(doi: 10.1186/s13321-018-0260-4)

Information-Derived Mechanistic Hypotheses for Structural Cardiotoxicity.

F Svensson, A Zoufir, S Mahmoud, AM Afzal, I Smit, KA Giblin, PJ Clements, JT Mettetal, A Pointon, JS Harvey, N Greene, RV Williams, A Bender

Chem Res Toxicol

(2018)

31

1119

(doi: 10.1021/acs.chemrestox.8b00159)

GBM Drug Bank-a new resource for glioblastoma drug discovery and informatics research

F Svensson, B Westerman, T Würdinger, D Bailey

Neuro-Oncology

(2018)

20

1680

(doi: 10.1093/neuonc/noy122)