Lewis Howard Mervin

Research Associate

Lewis joined the Bender research group at the Centre for Molecular Informatics in 2013 through a BBSRC/AstraZeneca CASE Studentship, following an undergraduate degree in Biology and Computing Science at the University of Manchester. His doctoral research involves the development of target prediction & Mechanism-of-Action (MoA) protocols which are publicly available via GitHub. This is an area of research which will be continued subsequently also in his postdoctoral project.

Publications

Leveraging heterogeneous data from GHS toxicity annotations, molecular and protein target descriptors and Tox21 assay readouts to predict and rationalise acute toxicity

CHG Allen, LH Mervin, SY Mahmoud, A Bender

Journal of Cheminformatics

(2019)

(doi: 10.1186/s13321-019-0356-5)

Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs

HR Noori, LH Mervin, V Bokharaie, Ö Durmus, L Egenrieder, S Fritze, B Gruhlke, G Reinhardt, H-H Schabel, S Staudenmaier, NK Logothetis, A Bender, R Spanagel

Nature Communications

(2018)

4699

(doi: 10.1038/s41467-018-07239-1)

Understanding and predicting disease relationships through similarity fusion

E Oerton, I Roberts, PSH Lewis, T Guilliams, A Bender

Bioinformatics

(2018)

1213

(doi: 10.1093/bioinformatics/bty754)

Extending in Silico Protein Target Prediction Models to Include Functional Effects

LH Mervin, AM Afzal, L Brive, O Engkvist, A Bender

Front Pharmacol

(2018)

613

(doi: 10.3389/fphar.2018.00613)

Computer-aided design of multi-target ligands at A₁R, A_2AR and PDE10A, key proteins in neurodegenerative diseases.

L Kalash, C Val, J Azuaje, MI Loza, F Svensson, A Zoufir, L Mervin, G Ladds, J Brea, R Glen, E Sotelo, A Bender

Journal of Cheminformatics

(2017)

(doi: 10.1186/s13321-017-0249-4)

Towards the mode of action of Strobilanthes crispus through integrated computational and experimental analyses

KK Wong, LH Mervin, A Mazzolari, A Bender, NS Yaacob

Journal of Plant Biochemistry and Biotechnology

(2017)

451

(doi: 10.1007/s13562-017-0407-9)

Orthologue chemical space and its influence on target prediction

LH Mervin

Bioinformatics

(2017)

(doi: 10.1093/bioinformatics/btx525)

Toward Understanding the Cold, Hot, and Neutral Nature of Chinese Medicines Using in Silico Mode-of-Action Analysis

X Fu, LH Mervin, X Li, H Yu, J Li, SZ Mohamad Zobir, A Zoufir, Y Zhou, Y Song, Z Wang, A Bender

Journal of Chemical Information and Modeling

(2017)

468

(doi: 10.1021/acs.jcim.6b00725)

Novel adamantanyl-based thiadiazolyl pyrazoles targeting EGFR in triple-negative breast cancer

A Sebastian, V Pandey, CD Mohan, YT Chia, S Rangappa, J Mathai, CP Baburajeev, S Paricharak, LH Mervin, KC Bulusu, JE Fuchs, A Bender, S Yamada, Basappa, PE Lobie, KS Rangappa

ACS omega

(2016)

1412

(doi: 10.1021/acsomega.6b00251)

Current Trends in Drug Sensitivity Prediction.

I Cortes-Ciriano, LH Mervin, A Bender

Current Pharmaceutical Design

(2016)

6918

(doi: 10.2174/1381612822666161026154430)

Lewis Howard Mervin

Research Associate

Publications

Telephone number

About the Department

Departmental Services

Bender Group

Study at Cambridge

About the University

Research at Cambridge