Data-Driven Drug Discovery and Molecular Informatics

Dr Isidro Cortes Ciriano

Research Fellow

Publications

Conformal Regression for Quantitative Structure-Activity Relationship Modeling-Quantifying Prediction Uncertainty
F Svensson, N Aniceto, U Norinder, I Cortes-Ciriano, O Spjuth, L Carlsson, A Bender
Journal of Chemical Information and Modeling
(2018)
58
(doi: 10.1021/acs.jcim.8b00054)
Comprehensive Characterization of Cancer Driver Genes and Mutations.
MH Bailey, C Tokheim, E Porta-Pardo, S Sengupta, D Bertrand, A Weerasinghe, A Colaprico, MC Wendl, J Kim, B Reardon, PK-S Ng, KJ Jeong, S Cao, Z Wang, J Gao, Q Gao, F Wang, EM Liu, L Mularoni, C Rubio-Perez, N Nagarajan, I Cortés-Ciriano, DC Zhou, W-W Liang, JM Hess, VD Yellapantula, D Tamborero, A Gonzalez-Perez, C Suphavilai, JY Ko, E Khurana, PJ Park, EM Van Allen, H Liang, MC3 Working Group, Cancer Genome Atlas Research Network, MS Lawrence, A Godzik, N Lopez-Bigas, J Stuart, D Wheeler, G Getz, K Chen, AJ Lazar, GB Mills, R Karchin, L Ding
Cell
(2018)
173
(doi: 10.1016/j.cell.2018.02.060)
Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
L Ding, MH Bailey, E Porta-Pardo, V Thorsson, A Colaprico, D Bertrand, DL Gibbs, A Weerasinghe, K-L Huang, C Tokheim, I Cortés-Ciriano, R Jayasinghe, F Chen, L Yu, S Sun, C Olsen, J Kim, AM Taylor, AD Cherniack, R Akbani, C Suphavilai, N Nagarajan, JM Stuart, GB Mills, MA Wyczalkowski, BG Vincent, CM Hutter, JC Zenklusen, KA Hoadley, MC Wendl, L Shmulevich, AJ Lazar, DA Wheeler, G Getz, Cancer Genome Atlas Research Network
Cell
(2018)
173
(doi: 10.1016/j.cell.2018.03.033)
Genomic footprints of activated telomere maintenance mechanisms in cancer
L Sieverling, C Hong, SD Koser, P Ginsbach, K Kleinheinz, B Hutter, DM Braun, I Cortés-Ciriano, R Xi, R Kabbe, PJ Park, R Eils, M Schlesner, K Rippe, DTW Jones, B Brors, L Feuerbach, PDAFIG PCAWG SNV Calling Working Group
(2017)
(doi: 10.1101/157560)
A molecular portrait of microsatellite instability across multiple cancers.
I Cortes-Ciriano, S Lee, W-Y Park, T-M Kim, PJ Park
Nat Commun
(2017)
8
(doi: 10.1038/ncomms15180)
Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.
MJ McConnell, JV Moran, A Abyzov, S Akbarian, T Bae, I Cortes-Ciriano, JA Erwin, L Fasching, DA Flasch, D Freed, J Ganz, AE Jaffe, KY Kwan, M Kwon, MA Lodato, RE Mills, ACM Paquola, RE Rodin, C Rosenbluh, N Sestan, MA Sherman, JH Shin, S Song, RE Straub, J Thorpe, DR Weinberger, AE Urban, B Zhou, FH Gage, T Lehner, G Senthil, CA Walsh, A Chess, E Courchesne, JG Gleeson, JM Kidd, PJ Park, J Pevsner, FM Vaccarino, Brain Somatic Mosaicism Network
Science
(2017)
356
(doi: 10.1126/science.aal1641)
Cancer Cell Line Profiler (CCLP): a webserver for the prediction of compound activity across the NCI60 panel
I Cortés-Ciriano, DS Murrell, B Chetrit, A Bender, T Malliavin, PJ Ballester
(2017)
(doi: 10.1101/105478)
Current Trends in Drug Sensitivity Prediction
I Cortes-Ciriano, LH Mervin, A Bender
Current pharmaceutical design
(2017)
22
(doi: 10.2174/1381612822666161026154430)
The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts
N Saini, SA Roberts, LJ Klimczak, K Chan, SA Grimm, S Dai, DC Fargo, JC Boyer, WK Kaufmann, JA Taylor, E Lee, I Cortes-Ciriano, PJ Park, SH Schurman, EP Malc, PA Mieczkowski, DA Gordenin
PLOS Genetics
(2016)
12
(doi: 10.1371/journal.pgen.1006385)
A molecular portrait of microsatellite instability across multiple cancers
I Cortes-Ciriano, S Lee, W-Y Park, T-M Kim, PJ Park
(2016)
(doi: 10.1101/079152)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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