Currently also: Chief Informatics and Technology Officer (CITO) at Pangea Botanica, London/UK and Berlin/Germany
Previous positions:
Director Digital Chemistry at NUVISAN Berlin
Associate Director Computational ADME and Safety (Clinical Pharmacology & Safety Sciences/Data Science and Artificial Intelligence - CPSS/DSAI) at AstraZeneca Cambridge
Co-founder of Healx Ltd.
Co-founder of PharmEnable Ltd.
- Committed to developing new life science data analysis methods (AI/ML/data science) and their application, primarily related to chemical biology, drug discovery and in silico toxicology
- Expertise comprises data ranging from chemical structure and gene expression data to phenotypic readouts and preclinical information, applied to both efficacy- and safety/tox-related questions
- Collaborating with academic research groups, as well as pharmaceutical, chemical, and consumer goods companies (Eli Lilly, AstraZeneca, GSK, BASF, Johnson&Johnson/Janssen, Unilever, ...)
- Co-founder/founding CTO and current SAB member of Healx Ltd. (data-driven drug repurposing for rare diseases, and beyond); co-founder of PharmEnable Ltd.; SAB member of Lhasa Ltd. (toxicology and metabolism prediction) and Cresset Ltd.
- Coordinator of the Computational & In Silico Toxicology Specialty Section of the British Toxicology Society (BTS)
- Steering Committee Member of the Cambridge Alliance on Medicines Safety (CAMS)
- Currently leading a group of ca. 15 PhD students, postdocs, project students and visitors at the Centre for Molecular Informatics at the University of Cambridge, https://www-cmi.ch.cam.ac.uk/centre-molecular-informatics
Publications
THE APPLICATION OF ITERATIVE SCREENING TO HIT IDENTIFICATION
(2020)
315
INTEGRATED NETWORK ANALYSIS USING PATIENT-SPECIFIC SINGLE NUCLEOTIDE POLYMORPHISM PROFILES UNCOVERS NEW PATHWAYS INVOLVED IN ULCERATIVE COLITIS PATHOGENESIS
GASTROENTEROLOGY
(2020)
158
S795
Chapter 5 Concepts and Applications of Conformal Prediction in Computational Drug Discovery
(2020)
63
(doi: 10.1039/9781788016841-00063)
Structural Chemogenomics Profiling Protein-Ligand Interactions in Polypharmacological Space
(2020)
53
Integrated network analysis using patient-specific single-nucleotide polymorphism profiles uncovers new pathways involved in ulcerative colitis pathogenesis
JOURNAL OF CROHNS & COLITIS
(2020)
14
S092
Bioinformatic Approaches in the Understanding of Mechanism of Action (MoA)
(2019)
323
(doi: 10.1002/9783527818242.ch11)
Applying synergy metrics to combination screening data: agreements, disagreements and pitfalls
Drug discovery today
(2019)
24
2286
(doi: 10.1016/j.drudis.2019.09.002)
Triazole‐Pyridine Dicarbonitrile Targets Phosphodiesterase 4 to Induce Cytotoxicity in Lung Carcinoma Cells
Chem Biodivers
(2019)
16
e1900234
(doi: 10.1002/cbdv.201900234)
Understanding Conditional Associations between ToxCast in Vitro Readouts and the Hepatotoxicity of Compounds Using Rule-Based Methods
Chemical Research in Toxicology
(2019)
33
137
- ‹ previous
- Page 11
