Professor Andreas Bender

Currently also: Chief Informatics and Technology Officer (CITO) at Pangea Botanica, London/UK and Berlin/Germany

Previous positions:

Director Digital Chemistry at NUVISAN Berlin

Associate Director Computational ADME and Safety (Clinical Pharmacology & Safety Sciences/Data Science and Artificial Intelligence - CPSS/DSAI) at AstraZeneca Cambridge

Co-founder of Healx Ltd.

Co-founder of PharmEnable Ltd.

Personal Website

Committed to developing new life science data analysis methods (AI/ML/data science) and their application, primarily related to chemical biology, drug discovery and in silico toxicology
Expertise comprises data ranging from chemical structure and gene expression data to phenotypic readouts and preclinical information, applied to both efficacy- and safety/tox-related questions
Collaborating with academic research groups, as well as pharmaceutical, chemical, and consumer goods companies (Eli Lilly, AstraZeneca, GSK, BASF, Johnson&Johnson/Janssen, Unilever, ...)
Co-founder/founding CTO and current SAB member of Healx Ltd. (data-driven drug repurposing for rare diseases, and beyond); co-founder of PharmEnable Ltd.; SAB member of Lhasa Ltd. (toxicology and metabolism prediction) and Cresset Ltd.
Coordinator of the Computational & In Silico Toxicology Specialty Section of the British Toxicology Society (BTS)
Steering Committee Member of the Cambridge Alliance on Medicines Safety (CAMS)
Currently leading a group of ca. 15 PhD students, postdocs, project students and visitors at the Centre for Molecular Informatics at the University of Cambridge, https://www-cmi.ch.cam.ac.uk/centre-molecular-informatics

Publications

EMDIP: An Entropy Measure to Discover Important Proteins in PPI networks.

H Bashiri, H Rahmani, V Bashiri, D Módos, A Bender

Comput Biol Med

(2020)

120

103740

(doi: 10.1016/j.compbiomed.2020.103740)

Establishing GPCR Targets of hMAO Active Anthraquinones from Cassia obtusifolia Linn Seeds Using In Silico and In Vitro Methods.

P Paudel, SH Seong, FM Fauzi, A Bender, HA Jung, JS Choi

ACS omega

(2020)

7705

(doi: 10.1021/acsomega.0c00684)

Prediction and mechanistic analysis of Drug-Induced Liver Injury (DILI) based on chemical structure

A Liu, M Walter, P Wright, AM Bartosik, D Dolciami, A Elbasir, H Yang, A Bender

(2020)

(doi: 10.21203/rs.3.rs-16599/v1)

Structural Chemogenomics Profiling Protein-Ligand Interactions in Polypharmacological Space

B Briels, C de Graaf, A Bender

(2020)

Integrated network analysis using patient-specific single-nucleotide polymorphism profiles uncovers new pathways involved in ulcerative colitis pathogenesis

D Modos, J Brooks, P Sudhakar, B Verstockt, B Alexander-Dann, A Zoufir, D Fazekas, S Vermeire, T Korcsmaros, A Bender

JOURNAL OF CROHNS & COLITIS

(2020)

S092

Chapter 5 Concepts and Applications of Conformal Prediction in Computational Drug Discovery

I Cortés-Ciriano, A Bender

(2020)

(doi: 10.1039/9781788016841-00063)

Drug Combination Modeling

AHC Vlot, DJ Mason, KC Bulusu, A Bender

(2020)

1-3

269

(doi: 10.1016/B978-0-12-801238-3.11569-7)

INTEGRATED NETWORK ANALYSIS USING PATIENT-SPECIFIC SINGLE NUCLEOTIDE POLYMORPHISM PROFILES UNCOVERS NEW PATHWAYS INVOLVED IN ULCERATIVE COLITIS PATHOGENESIS

D Modos, J Brooks, P Sudhakar, B Verstockt, B Alexander-Dann, A Zoufir, D Fazekas, S Carding, S Vermeire, A Bender, T Korcsmaros

GASTROENTEROLOGY

(2020)

158

S795

THE APPLICATION OF ITERATIVE SCREENING TO HIT IDENTIFICATION

F Svensson, A Bender, U Norinder

(2020)

315

Bioinformatic Approaches in the Understanding of Mechanism of Action (MoA)

M Trapotsi, I Barrett, O Engkvist, A Bender

(2019)

323

(doi: 10.1002/9783527818242.ch11)

Professor Andreas Bender

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