Dr Leen Kalash

Publications

Synthesis of CC, CN coupled novel substituted dibutyl benzothiazepinone derivatives and evaluation of their thrombin inhibitory activity.

CP Baburajeev, CD Mohan, V Pandey, S Rangappa, N Shivalingegowda, L Kalash, S Devaraja, A Bender, PE Lobie, KS Rangappa, Basappa

Bioorg Chem

(2019)

142

Synthesis of Structurally Diverse N-Substituted Quaternary-Carbon-Containing Small Molecules from α,α-Disubstituted Propargyl Amino Esters

N Mateu, SL Kidd, L Kalash, HF Sore, A Madin, A Bender, DR Spring

Chemistry (Weinheim an der Bergstrasse, Germany)

(2018)

13681

Structure-based design of allosteric calpain-1 inhibitors populating a novel bioactivity space

L Kalash, J Cresser-Brown, J Habchi, C Morgan, DJ Miller, RC Glen, RK Allemann, A Bender

European journal of medicinal chemistry

(2018)

157

1264

Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases.

L Kalash, C Val, J Azuaje, MI Loza, F Svensson, A Zoufir, L Mervin, G Ladds, J Brea, R Glen, E Sotelo, A Bender

Journal of cheminformatics

(2017)

Orthologue chemical space and its influence on target prediction

LH Mervin

Bioinformatics (Oxford, England)

(2017)